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"Reforming Healthcare by preventing diseases through next generation vaccines”.

Publications

Lech PJ, Tobin GJ, Bushnell R, Gutschenritter E, Pham LD, Nace R,  
Verhoeyen E, Cosset FL, Muller CP, Russell SJ, Nara PL. Epitope  
dampening monotypic measles virus hemagglutinin glycoprotein results  
in resistance to cocktail of monoclonal antibodies. PLoS One.  
2013;8(1):e52306. doi: 10.1371/journal.pone.0052306. Epub 2013 Jan 3.

Sun X, Wertz N, Lager K, Sinkora M, Stepanova K, Tobin G, Butler JE.  
Antibody repertoire development in fetal and neonatal piglets. XXII. ?  
Rearrangement precedes ? rearrangement during B-cell lymphogenesis in  
swine. Immunology. 2012 Oct;137(2):149-59.

Sun XZ, Wertz N, Lager K, Sinkora M, Stepanova K, Tobin G, Butler JE.  
Antibody repertoire development in fetal and neonatal piglets. XXII.  
Lambda rearrangement precedes kappa rearrangement during B cell  
lymphogenesis in swine. Immunology. 2012 Jun 21. doi:  
10.1111/j.1365-2567.2012.03615.x

Sun XZ, Wertz N, Lager KL, Tobin G, Butler JE. Antibody repertoire  
development in fetal and neonatal piglets. XXIII: fetal piglets  
infected with a vaccine strain of PRRS Virus display the same immune  
dysregulation seen in isolator piglets. Vaccine. 2012 May  
21;30(24):3646-52

Annamalay A.A.,  Khoo S.-K, Jacoby P., Bizzintino J., Zhang G.,  
Chidlow G., Lee W.-M, Moore H.C., Harnett G.B., Smith D.W., Gern J.E.,  
LeSouef P.N., Laing I.A., Lehmann D., 2012. Human Rhinoviruses in  
Healthy Aboriginal and non-Aboriginal Western Australian Children:  
Prevalence and Risk Factors. The Pediatric Infectious Disease Journal.  
31:673-679.

Colvin J.M., Muenzer J.T., Jaffe D.M., Smason A., Deych E., Shannon  
W.D., Arens M.Q., Buller R.S., Lee W.-M., Sodergren-Weinstock E.J.,  
Weinstock G.M., Storch G.A., 2012. Detection of Viruses in Young  
Children with Fever without an Apparent Source. Pediatrics. In press.
Gern J.E., Pappas T., Visness C.M, Jaffee K.F., Lemanske R.F., Togias  
A., and Lee W.-M. 2012. Comparison of the Etiology of Viral  
Respiratory Illnesses in Inner-City and Suburban Infants. J Infect  
Dis. 206:1342-9.

Jackson D., Evans M.D., Gangnon R.E., Tisler C.J., Pappas T., Lee  
W.-M., Gern J.E., and Lemanske R.F. 2012. Evidence for a Causal  
Relationship Between Allergic Sensitization and Rhinovirus Wheezing in  
Early Life. Am. J. Respir. Crit. Care. Med. 185:281-285.

Kloepfer K. M., Olenec J. P., Lee W.-M., Pappas T. E., Liu G., Vrtis  
R., Lemanske R. F., Evans M., Gangnon R. and Gern J. E. 2012.  
Increased H1N1 Infection Rate in Asthmatic Children. Am. J. Respir.  
Crit. Care. Med. 185:1275-1279.

Lee W.-M., Lemanske R. F., Evans M., Vang F., Pappas T. E., Gangnon  
R., Jackson D. and Gern J. E.. 2012. Human Rhinovirus Species and  
Season of Infection Determine Illness Severity. Am. J. Respir. Crit.  
Care. Med. 186:886-91.

Tao S., Zhu L., Lee P., Lee W.-M., Di Y.P., Knox K., Chen J., and Chen  
Y. 2012. Negative control of TLR3 signaling through TICAM1  
downregulation. Am J Respir Cell Mol Biol. 46: 660-667.

Butler, JE, Sun X, Wertz N, Lager KM, Chaloner K, Urban J Jr, Francis  
DL, Nara PL, Tobin GJ. Antibody repertoire development in fetal and  
neonatal piglets XXI. Usage of most VH genes remains constant during  
fetal and postnatal development. Mol Immunol. 2011 Dec;49(3):483-94.  
Epub 2011 Oct 21.

Long J, Bushnell RV, Tobin JK, Pan K, Deem MW, Nara PL, Tobin GJ  
Evolution of H3N2 influenza virus in a Guinea pig model.  PloS ONE  
2011;6(7) e20130 July 2011

Asad A., Gern J.E., Hartert T.V., Edwards K.M., Griffin M.R., Miller  
E.K., Gebretsadik T., Pappas T., Lee W.-M., Williams J.V.. 2011.  
Real-world comparison of two molecular methods for detection of  
respiratory viruses. Virol J. 8: 332.

Bizzintino J., Lee W.-M., Laing I.A., Vang F., Pappas T., Zhang G.,  
Martin A.C., Geelhoed G.C., McMinn P.C., Goldblatt J., Gern J.E., and  
Le Souëf P.N. 2011 Association between human rhinovirus C and severity  
of acute asthma in children. European Respiratory Journal 37:1037-1042.

Chattoraj, S. S., S. Ganesan, A. Faris, A. Comstock, W.-M. Lee, and U.  
S. Sajjan. 2011. Pseudomonas aeruginosa suppresses interferon response  
to rhinovirus infection in cystic fibrosis but not in normal bronchial  
epithelial cells. Infect Immun. 79: 4131-4145.

Denlinger L. C., Sorkness R. L., Lee W.-M., Evans M. D., Wolff M.,  
Mathur S., Swenson C., Crisafi G., Gaworski K., Pappas T. E., Vrtis  
R., Kelly E. A., Gern J. E., and Jarjour N. N.. 2011. Lower Airway  
Rhinovirus Burden and the Risk of Asthma Exacerbation. Am. J. Respir.  
Crit. Care. Med. 184:1007-1014

Jinxue Long, Ruth V. Bushnell, John K. Tobin, Keyao Pan, Michael W.  
Deem, Peter L. Nara, and Gregory J. Tobin.
Evolution of H3N2 Influenza Virus in a Guinea Pig Model.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142111/?tool=pubmed

Peter L. Nara, Gregory J. Tobin, A. Ray Chaudhuri, Jessie D. Trujillo,  
George Lin, Michael W. Cho, Simon A. Levin, Wilfred Ndifon, Ned S.  
Wingreen
How Can Vaccines Against Influenza and Other Viral Diseases Be Made  
More Effective?
PLoS Biol. 2010 December; 8(12): e1000571. Published online 2010 December 21.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006352/?tool=pmcentrez

Nara PL, GJ Tobin, AR Chaudhuri, JD Trujillo, G Lin, M Cho, SA Levin,  
W Ndifon, NS Wingreen. How can vaccine designs against influenza and  
other viral diseases be made more effective? PLOS Pathogens, December  
2010

Keyao Pan, Jinxue Long, Haoxin Sun, Gregory J. Tobin, Peter L. Nara,  
Michael W. Deem
Selective Pressure to Increase Charge in Immunodominant Epitopes of  
the H3 Hemagglutinin Influenza Protein
J Mol Evol. 2011 January; 72(1): 90?103. Published online 2010 November 18.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033527/?tool=pmcentrez

Pan K, J Long, XZ Sun, GJ Tobin, PL Nara and MW Deem. Selective  
Pressure to Increase Charge in Immunodominant Epitopes of the H3  
Hemagglutinin Influenza Protein., J Mol Evol. 2010 Nov 18
Wolfram JH, Nara PL. Exchange and sharing of new information,  
experiences, and approaches to controlling, reducing, and eventually  
eradicating different types of diseases. Conclusion. Vaccine. 2010 Oct  
1;28 Suppl 5:F85-8. No abstract available.
http://www.ncbi.nlm.nih.gov/pubmed/20891047

Wolfram JH, Nara PL.
Brucellosis as a Transboudary Infection of Animals and Humans which  
Needs to be Managed by Cooperative Efforts of Different Countries.  
Introduction. Vaccine. 2010 Oct 1;28 Suppl 5:F1-2.
http://www.ncbi.nlm.nih.gov/pubmed/20850687

Bushnell RV , Tobin JK, Long J, Schultz-Cherry S, Chaudhuri AR, Nara  
PL, Tobin GJ.
Serological characterization of guinea pigs infected with H3N2 human  
influenza or immunized with hemagglutinin protein. Virol J. 2010 Aug  
24;7:200.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939558/?tool=pmcentrez

Eguchi-Ogawa T, Wertz N, Sun XZ, Puimi F, Uenishi H, Wells K, Chardon  
P, Tobin GJ, Butler JE.
Antibody repertoire development in fetal and neonatal piglets. XI. The  
relationship of variable heavy chain gene usage and the genomic  
organization of the variable heavy chain locus.
J Immunol. 2010 Apr 1;184(7):3734-42. Epub 2010 Mar 5.
http://www.ncbi.nlm.nih.gov/pubmed/20207992

Sponseller BA, Strait E, Jergens A, Trujillo J, Harmon K, Koster L,  
Jenkins-Moore M, Killian M, Swenson S, Bender H, Waller K, Miles K,  
Pearce T, Yoon KJ, Nara P. Influenza A pandemic (H1N1) 2009 virus  
infection in domestic cat.
Emerg Infect Dis. 2010 Mar;16(3):534-7.
http://www.ncbi.nlm.nih.gov/pubmed/20202440

Arens M.Q., Buller R.S., Rankin A., Mason S., Whetsell1 A., Agapov E.,  
Lee W.-M., and Storch G.A. 2010. Comparison of the Eragen Multi-Code®  
Respiratory Virus Panel with Conventional Viral Testing and Real-Time  
Multiplex PCR Assays for Respiratory Viruses.  J Clin Microbiol.  
48:2387-95.

Bochkova, Y. A., Palmenberg A. C., Lee W.-M., Rathe J. A., Amineva S.  
P., Sun X., T. R., Pasicd N., Jarjour N., Liggett S. B., and Gern J.  
E.. 2010. Molecular modeling, organ culture and reverse genetics of  
the emerging pathogen human rhinovirus C. Nature Medicine 17:627-632.

Bushnell RV, Tobin JK, Long J, Schultz-Cherry S, Chaudhuri AR, Nara  
PL, Tobin GJ.  Serological characterization of guinea pigs infected  
with H3N2 human influenza or immunized with hemagglutinin protein.  
Virol J 7:200.  2010.

Eguchi-Ogawa T, Wertz N, Sun XZ, Puimi F, Uenishi H, Wells K, Chardon  
P, Tobin GJ, Butler JE. Antibody repertoire development in fetal and  
neonatal piglets. XI. The relationship of variable heavy chain gene  
usage and the genomic organization of the variable heavy chain locus.  
J Immunol.184:3734-42.2010

Jurgeit, A., S. Moese, P. Roulin, A. Dorsch, M. Lötzerich, W.-M. Lee,  
and U. F. Greber. 2010. An RNA replication-center assay for high  
content image-based quantifications of human rhinovirus and  
coxsackievirus infections. Virology Journal. 7:264 -277.

Linderholm A., Onitsuka J., Xu C., Chiu M., Lee W.-M., and Harper R.  
2010 All-Trans Retinoic Acid Mediates Duox2 Expression and Function in  
Respiratory Tract Epithelium. Am J Physiol Lung Cell Mol Physiol.  
299:L215-221.

Olenec J.P., Kim W.K., Lee W.-M., Vang F., Pappas T.E., Salazar L.E.,  
Evans M.D., Bork J., Roberg K., Lemanske R.F. Jr, Gern J.E. 2010.  
Weekly Monitoring of Children with Asthma for Infections and Illness  
During Common Cold Seasons. J Allergy Clin Immunol. 125:1001-1006

Turner R.B, and Lee W.-M. 2009 Rhinovirus. In: Richman DD, Whitley RJ,  
Hayden FG, eds. Clinical virology. 3rd ed. Washington, D.C.: ASM  
Press. 1063-1082.

Tobin GJ, Trujillo JD, Bushnell RV, Lin G, Chaudhuri AR,Long J,  
Barrera J, Pena L, Grubman, MJ and Nara PL.
Deceptive imprinting and immune refocusing in vaccine design. Vaccine  
26:6189-6199, 2008.
http://www.ncbi.nlm.nih.gov/pubmed/18852005

Nara PL, Nara D, Chaudhuri AR, Lin G, and Tobin GJ
Perspectives on advancing preventative medicine through vaccinology at  
the comparative veterinary, human and conservation medicine interface:  
Not missing the opportunities. Vaccine 26:6200-6211, 2008.
http://www.ncbi.nlm.nih.gov/pubmed/18708109

Lin G, Nara PL.
Designing immunogens to elicit broadly neutralizing antibodies to the  
HIV-1 envelope glycoprotein. Curr HIV Res. 5:514-41, 2007 Review.
http://www.ncbi.nlm.nih.gov/pubmed/18045109

Gay CG, Richie TL, Pastoret PP, Minguez-Tudela I, de Baetselier P,  
Göbel T, Goddeeris B, Kaiser P, Morrison I, Sánchez-Vizcaíno JM,  
Anderson K, Baillie LW, Brown WC, Estes DM, Herrera E, Nara PL,  
Ockenhouse CF, Roth JA, Sztein MB.    Advances in immunology and  
vaccine discovery report of the United States-European Commission  
workshop.
Vaccine. 2007 Oct 10;25(41):7007-11. Epub 2007 Aug 6.
http://www.ncbi.nlm.nih.gov/pubmed/17728022

Nara PL, Lin G. HIV-1: the confounding variables of virus neutralization.
Curr Drug Targets Infect Disord. 2005 Jun;5(2):157-70. Review.
http://www.ncbi.nlm.nih.gov/pubmed/15975021

Nara PL. The status and role of vaccines in the U.S. food animal  
industry. Implications for biological terrorism.
Ann N Y Acad Sci. 1999;894:206-17. Review.
http://www.ncbi.nlm.nih.gov/pubmed/10681992

Kohler H, Muller S, Schiffer M, Nara PL. Few clues for AIDS vaccines  
from structural data on gp120 and its receptors and antibodies
J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):315-6.
http://www.ncbi.nlm.nih.gov/pubmed/10077183

Garrity RR, Rimmelzwaan G, Minassian A, Tsai WP, Lin G, de Jong JJ,  
Goudsmit J, Nara PL. Refocusing neutralizing antibody response by  
targeted dampening of an immunodominant epitope.
J Immunol. 1997 Jul 1;159(1):279-89.
http://www.ncbi.nlm.nih.gov/pubmed/9200464

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