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"Reforming Healthcare by preventing diseases through next generation vaccines”.

Selected published works of Gregory J. Tobin, PhD.

Tobin GJ, Tobin JK, Gaidamakova EK, Wiggins TJ, Bushnell RV, Matrosova RY, Dollery SJ, Lee W-M, Meeks HN, Kouiavskaia D, Chumakov K, and Michael J. Daly MJ. A novel gamma radiation-inactivated Sabin-based polio vaccine. PLoS One. 2020; 15(1): e0228006. Published online 2020 Jan 30. doi: 10.1371/journal.pone.0228006.

Tobin GJ, Nara, PL, Lin, G. Immunogenic Influenza Composition. US 20200129611 April 30, 2020.

Tobin GJ and Nara PL. Immunogenic Human Rhinovirus (HRV) Composition US20180064802. Mar 8, 2018.

Nara, PL, Tobin, GJ, Lin, G. Immunogenic Influenza Composition US 20150313989. Nov 5, 2015.

Lech PJ, Pappoe R, Nakamura T, Tobin GJ, Nara PL, Russell SJ. Antibody neutralization of retargeted measles viruses. Virology. 2014 Apr;454-455:237-46. doi: 10.1016/j.virol.2014.01.027

Lech PJ, Tobin GJ, Bushnell R, Gutschenritter E, Pham LD, Nace R, Verhoeyen E, Cosset FL, Muller CP, Russell SJ, Nara PL. Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies. PLoS One. 2013;8(1):e52306.

Tobin, GJ and Nara, PN, Immunogenic human rhinovirus (HRV) compositions. US Patent 9,872,899. Awarded 1/23/2018, priority date 3/15/2013.

Long J, Bushnell RV, Tobin JK, Pan K, Deem MW, Nara PL, Tobin GJ. Evolution of H3N2 influenza virus in a guinea pig model. PLoS One. 2011;6(7):e20130. doi: 10.1371/journal.pone.0020130.

Butler JE, Sun X, Wertz N, Lager KM, Chaloner K, Urban J Jr, Francis DL, Nara PL, Tobin GJ. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Mol Immunol. 2011 Dec;49(3):483-94.

Bushnell RV, Tobin JK, Long J, Schultz-Cherry S, Chaudhuri AR, Nara PL, Tobin GJ.  Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein. Virol J 7:200.  2010.

Eguchi-Ogawa T, Wertz N, Sun XZ, Puimi F, Uenishi H, Wells K, Chardon P, Tobin GJ, Butler JE. Antibody repertoire development in fetal and neonatal piglets. XI. The relationship of variable H-chain gene usage and the genomic organization of the variable H- chain locus. J Immunol.184:3734-42.2010

Pan K, J Long, XZ Sun, GJ Tobin, PL Nara and MW Deem. Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein., J Mol Evol. 2010 Nov 18

Nara PL, GJ Tobin, AR Chaudhuri, JD Trujillo, G Lin, M Cho, SA Levin, W Ndifon, NS Wingreen. How can vaccine designs against influenza and other viral diseases be made more effective? PLOS Pathogens, December 2010

Nara PL, Nara D, Chaudhuri R, Lin G, Tobin G. Perspectives on advancing preventative medicine through vaccinology at the comparative veterinary, human and conservation medicine interface: Not missing the opportunities. Vaccine. 26:6200-11 (2008).

Tobin, GJ, JD Trujillo, RV Bushnell, G Lin, AR Chaudhuri, J Long, J Barrera, L Pena, MJ Grubman and PL Nara. Deceptive Imprinting and Immune Refocusing in Vaccine Design. Vaccine. 2008 26:6189-99. (2008)

Nara, PN, Tobin GJ, and Lin G, Immunogenic influenza composition. EP2254593A2. Awarded 2/22/2018, priority date 2/21/2008.

Yang QE, Fong SE, Li K, Gonda MA, Tobin GJ. Med Sci Monit. Ex vivo expanded murine bone marrow cells with a multiple cytokine cocktail retain long-term hematopoietic reconstitution potentials. 2005 Jun;11(6):BR154-161. Epub 2005 May 25.

Pletnev S, E Magracheva, S Kozlov, G. Tobin, SV Kotenko, A Wlodawer, and A Zdanov.  Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. Biochemistry 42:1217-24 (2003).

Chang, C., E Magracheva, S Kozlov, S Fong, G Tobin, S Kotenko, A Wlodawer, A Zdanov.  Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.  J. Biol Chem 278:3308-13 (2003).

Forns X, Emerson SU, Tobin GJ, Mushahwar IK, Purcell RH, Bukh J. DNA immunization of mice and macaques with plasmids encoding hepatitis C virus envelope E2 protein expressed intracellularly and on the cell surface. Vaccine. 1999 Apr 9;17(15-16):1992-2002.

Howard, O. M. Z., C. Winkler, M. Carrington, S. O'Brien, G. J. Tobin, and M. Dean.  Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function. J Biol 274:16228-34,1999.

Kervinen, J., G. J. Tobin, J,. Costa, D.S. Waugh, A. Wlodawer, and A. Zadnov.  Crystal structure of  plant aspartyl proteinase prophytepsin: the modes of inactivation and vacuolar targeting. EMBO J 18:3947-55,1999.

Rafnar, B., G.J. Tobin, K. Nagashima, M.A. Gonda, E. Gunnarsson, O.S. Andresson, G. Georgsson, and S. Torsteinsdottir.  Immune response to the visna virus Gag and Env proteins expressed in insect cells. Virus Res 53:107-20, 1998.

Glathe. S., J. Kervinen, M. Nimtz, G.H. Li, G.J. Tobin, T.D. Copeland, D.A. Ashford, A. Wlodawer, J. Costa. Transport and activation of the vacuolar aspartic proteinase phytepsin in barley (Hordeum vulgare L.). J Biol Chem 273:31230-6, 1998.

Fong, S.E., J.D. Greenwood, J.C. Williamson, D. Derse, L.A. Pallansch, T. Copeland, G.J. Tobin, L.Rasmussen, A. Mentzer, K. Nagashima, and M.A. Gonda.  Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene products.  Virology. 233:339-57, 1997.

Tobin, G.J., G. Li, K. Nagashima, S.E. Fong, and M.A. Gonda.  Chimeric HIV-1 like particles containinggp120 epitopes as a result of a ribosomal frameshift elicit Gag- and SU-specific murine cytotoxic T-lymphocyte activities.  Virology 236:307-315, 1997.

Tobin, GJ and Gonda MA, Chimeric Gag pseudovirions. US6099847A awarded 8/8/2000, priority date 5/15/1997

Tobin, G.J., K. Nagashima, and M.A. Gonda.  Immunologic and ultrastructural characterization of human immunodeficiency virus type 1 pseudovirions containing Gag and Env precursor proteins engineered in insect cells.  Methods: A Companion to Methods in Enzymology. 10:208-218, 1996.

Tobin, G.J., K. Nagashima, and M.A. Gonda.   Use of the particle-forming properties of the HIVGag precursor for packaging additional viral epitopes into pseudovirions produced in the baculovirus-insect cell expression system.  Intervirology 39:40-48, 1996. 

Tobin, G.J., W.E. Ennis, D. Clanton, and M.A. Gonda.  Inhibition of bovine immunodeficiency Virus by anti-HIV-1 compounds in a cell-based assay.  Antiviral Research 33:21-31, 1996.

Tobin, G.J., J.K. Battles, L. Rasmussen, and M.A. Gonda.  Assembly of recombinant retroviral Gag precursors into pseudovirions in the baculovirus-insect cell expression system.  In Methods in Molecular Genetics, Vol. 7, Molecular Virology.  K.W. Adolph, ed.  Academic Press, Orlando, pp. 237-253, 1995.

Walder, R., Z. Kalvatchev, G.J. Tobin, M.N. Barrios, D.J. Garzaro, and M.A. Gonda.  Possible role of bovine immunodeficiency virus in bovine paraplegic syndrome: evidence from immunochemical, virological and seroprevelance studies.  Res. Virol., 146:313-323, 1995.

Tobin, G.J., R C Sowder, 2nd, D Fabris, M Y Hu, J K Battles, C Fenselau, L E Henderson, M A Gonda Amino acid sequence analysis of the proteolytic cleavage products of the bovine immunodeficiency virus Gag precursor polypeptide. J Virol. 1994 Nov; 68(11): 7620–7627.

Gonda,M.A., D.G. Luther, S.E. Fong, and G.J. Tobin.  Bovine immunodeficiency virus: molecular biology and virus-host interactions.  Virus Res., 32:155-181, 1994.

Andrésson, Ó.S., J.E. Elser, G. Georgsson, G.J. Tobin, J.D. Greenwood, M.A. Gonda, V. Andrésdottir, P.A. Pálsson, and G. Pétursson.  Pathogenic proviral molecular clone of neurovirulent visna virus.  Ann. N.Y. Acad. Sci., 724:133-139, 1994. 

Gonda, M.A., S.E. Fong, and G.J. Tobin. Bovine immunodeficiency virus: emerging biology of a nonacute pathogenic lentivirus of cattle.  Food Microbiol., 11:149-160, 1994.

Andrésson, Ó.S., J.E. Elser, G.J. Tobin, J.D. Greenwood, M.A. Gonda, G., Georgsson, V. Andrésdóttir, E. Benediktsdóttir, H.M. Carlsdóttir, E.O. Mäntylä, B. Rafnar, P.A. Pálsson, J.W. Casey, and G. Pétursson.  Nucleotide sequence and biological properties of a pathogenic proviral molecular clone of neurovirulent visna virus.  Virology, 193:89-105, 1993.

Battles, J.K., M.Y. Hu, L. Rasmussen, G.J. Tobin, and M.A. Gonda.  Immunological characterization of the gag gene products of bovine immunodeficiency virus.  J. Virol., 66:6868-6877, 1992.

Chen J, Tobin GJ, Pipas JM, Van Dyke T. T-antigen mutant activities in vivo: roles of p53 and pRB binding in tumorigenesis of the choroid plexus. Oncogene. 1992 Jun;7(6):1167-75.

Tobin, G.J., D.C. Young, and J.B. Flanegan.  Self-catalyzed linkage of poliovirus terminal protein VPg to poliovirus RNA.  Cell, 59:511-519, 1989.

Oberste, M.S., G.J. Tobin, and J.B. Flanegan.  RNA binding and replication by the poliovirus RNA polymerase.  J. Cell. Biochem. suppl. 12D:42, 1988.

Young D.C., Tobin G.J., Flanegan, J.B. Characterization of product RNAs synthesized in vitro by poliovirus RNA polymerase purified by chromatography on hydroxylapatite or poly(U) Sepharose. J Virol. 1987 Feb; 61(2): 611–614.

Young, D.C., B.M. Dunn, G.J. Tobin, and J.B. Flanegan.  Anti-Vpg antibody immunoprecipitation of product RNA synthesized in vitro by the poliovirus polymerase and host factor is mediated by Vpg on the poliovirion RNA template.  J. Virol., 55:715-723, 1986.

Newcomb, W.W., G.J. Tobin, J.J. McGowan, and J.C. Brown.  In vitro reassembly of vesicular stomatitis virus skeletons. J. Virol., 41:1055-1062, 1982.

Download Dr. Tobin's Selected Published Words PDF.

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