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"Reforming Healthcare by preventing diseases through next generation vaccines”.

Publications

Tobin GJ, Tobin JK, Gaidamakova EK, Wiggins TJ, Bushnell RV, Matrosova RY, Dollery SJ, Lee W-M, Meeks HN, Kouiavskaia D, Chumakov K, and Michael J. Daly MJ. A novel gamma radiation-inactivated Sabin-based polio vaccine. PLoS ONE 2020 Jan 30;15(1):e0228006. doi: 10.1371/journal.pone.0228006. eCollection 2020

Lech PJ, Pappoe R, Nakamura T, Tobin GJ, Nara PL, Russell SJ. Antibody neutralization of retargeted measles viruses. Virology. 2014 Apr;454-455:237-46. doi: 10.1016/j.virol.2014.01.027

Lech PJ, Tobin GJ, Bushnell R, Gutschenritter E, Pham LD, Nace R, Verhoeyen E, Cosset FL, Muller CP, Russell SJ, Nara PL. Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies. PLoS One. 2013;8(1):e52306.

Long J, Bushnell RV, Tobin JK, Pan K, Deem MW, Nara PL, Tobin GJ. Evolution of H3N2 influenza virus in a guinea pig model. PLoS One. 2011;6(7):e20130. doi: 10.1371/journal.pone.0020130.

Butler JE, Sun X, Wertz N, Lager KM, Chaloner K, Urban J Jr, Francis DL, Nara PL, Tobin GJ. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Mol Immunol. 2011 Dec;49(3):483-94.

Nara PL, GJ Tobin, AR Chaudhuri, JD Trujillo, G Lin, M Cho, SA Levin, W Ndifon, NS Wingreen. How can vaccine designs against influenza and other viral diseases be made more effective? PLOS Pathogens, December 2010

Bushnell RV, Tobin JK, Long J, Schultz-Cherry S, Chaudhuri AR, Nara PL, Tobin GJ.  Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein. Virol J 7:200.  2010.

Pan K, J Long, XZ Sun, GJ Tobin, PL Nara and MW Deem. Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein., J Mol Evol. 2010 Nov 18

Lech PJ, Tobin GJ, Bushnell R, Gutschenritter E, Pham LD, Nace R, Verhoeyen E, Cosset FL, Muller CP, Russell SJ, Nara PL. Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies. PLoS One. 2013;8(1):e52306. doi: 10.1371/journal.pone.0052306. Epub 2013 Jan 3.

Sun X, Wertz N, Lager K, Sinkora M, Stepanova K, Tobin G, Butler JE. Antibody repertoire development in fetal and neonatal piglets. XXII. ? Rearrangement precedes ? rearrangement during B-cell lymphogenesis in swine. Immunology. 2012 Oct;137(2):149-59.

Sun XZ, Wertz N, Lager K, Sinkora M, Stepanova K, Tobin G, Butler JE. Antibody repertoire development in fetal and neonatal piglets. XXII. Lambda rearrangement precedes kappa rearrangement during B cell lymphogenesis in swine. Immunology. 2012 Jun 21. doi: 10.1111/j.1365-2567.2012.03615.x

Sun XZ, Wertz N, Lager KL, Tobin G, Butler JE. Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS Virus display the same immune dysregulation seen in isolator piglets. Vaccine. 2012 May 21;30(24):3646-52

Annamalay A.A.,  Khoo S.-K, Jacoby P., Bizzintino J., Zhang G., Chidlow G., Lee W.-M, Moore H.C., Harnett G.B., Smith D.W., Gern J.E., LeSouef P.N., Laing I.A., Lehmann D., 2012. Human Rhinoviruses in Healthy Aboriginal and non-Aboriginal Western Australian Children: Prevalence and Risk Factors. The Pediatric Infectious Disease Journal. 31:673-679.

Colvin J.M., Muenzer J.T., Jaffe D.M., Smason A., Deych E., Shannon W.D., Arens M.Q., Buller R.S., Lee W.-M., Sodergren-Weinstock E.J., Weinstock G.M., Storch G.A., 2012. Detection of Viruses in Young Children with Fever without an Apparent Source. Pediatrics. In press.
Gern J.E., Pappas T., Visness C.M, Jaffee K.F., Lemanske R.F., Togias A., and Lee W.-M. 2012. Comparison of the Etiology of Viral Respiratory Illnesses in Inner-City and Suburban Infants. J Infect Dis. 206:1342-9.

Jackson D., Evans M.D., Gangnon R.E., Tisler C.J., Pappas T., Lee W.-M., Gern J.E., and Lemanske R.F. 2012. Evidence for a Causal Relationship Between Allergic Sensitization and Rhinovirus Wheezing in Early Life. Am. J. Respir. Crit. Care. Med. 185:281-285.

Kloepfer K. M., Olenec J. P., Lee W.-M., Pappas T. E., Liu G., Vrtis R., Lemanske R. F., Evans M., Gangnon R. and Gern J. E. 2012. Increased H1N1 Infection Rate in Asthmatic Children. Am. J. Respir. Crit. Care. Med. 185:1275-1279.

Lee W.-M., Lemanske R. F., Evans M., Vang F., Pappas T. E., Gangnon R., Jackson D. and Gern J. E.. 2012. Human Rhinovirus Species and Season of Infection Determine Illness Severity. Am. J. Respir. Crit. Care. Med. 186:886-91.

Tao S., Zhu L., Lee P., Lee W.-M., Di Y.P., Knox K., Chen J., and Chen Y. 2012. Negative control of TLR3 signaling through TICAM1 downregulation. Am J Respir Cell Mol Biol. 46: 660-667.

Butler, JE, Sun X, Wertz N, Lager KM, Chaloner K, Urban J Jr, Francis DL, Nara PL, Tobin GJ. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Mol Immunol. 2011 Dec;49(3):483-94. Epub 2011 Oct 21.

Long J, Bushnell RV, Tobin JK, Pan K, Deem MW, Nara PL, Tobin GJ Evolution of H3N2 influenza virus in a Guinea pig model.  PloS ONE 2011;6(7) e20130 July 2011

Asad A., Gern J.E., Hartert T.V., Edwards K.M., Griffin M.R., Miller E.K., Gebretsadik T., Pappas T., Lee W.-M., Williams J.V.. 2011. Real-world comparison of two molecular methods for detection of respiratory viruses. Virol J. 8: 332.

Bizzintino J., Lee W.-M., Laing I.A., Vang F., Pappas T., Zhang G., Martin A.C., Geelhoed G.C., McMinn P.C., Goldblatt J., Gern J.E., and Le Souëf P.N. 2011 Association between human rhinovirus C and severity of acute asthma in children. European Respiratory Journal 37:1037-1042.

Chattoraj, S. S., S. Ganesan, A. Faris, A. Comstock, W.-M. Lee, and U. S. Sajjan. 2011. Pseudomonas aeruginosa suppresses interferon response to rhinovirus infection in cystic fibrosis but not in normal bronchial epithelial cells. Infect Immun. 79: 4131-4145.

Denlinger L. C., Sorkness R. L., Lee W.-M., Evans M. D., Wolff M., Mathur S., Swenson C., Crisafi G., Gaworski K., Pappas T. E., Vrtis R., Kelly E. A., Gern J. E., and Jarjour N. N.. 2011. Lower Airway Rhinovirus Burden and the Risk of Asthma Exacerbation. Am. J. Respir. Crit. Care. Med. 184:1007-1014

Jinxue Long, Ruth V. Bushnell, John K. Tobin, Keyao Pan, Michael W. Deem, Peter L. Nara, and Gregory J. Tobin.
Evolution of H3N2 Influenza Virus in a Guinea Pig Model.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142111/?tool=pubmed

Peter L. Nara, Gregory J. Tobin, A. Ray Chaudhuri, Jessie D. Trujillo, George Lin, Michael W. Cho, Simon A. Levin, Wilfred Ndifon, Ned S. Wingreen
How Can Vaccines Against Influenza and Other Viral Diseases Be Made More Effective?
PLoS Biol. 2010 December; 8(12): e1000571. Published online 2010 December 21.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006352/?tool=pmcentrez

Nara PL, GJ Tobin, AR Chaudhuri, JD Trujillo, G Lin, M Cho, SA Levin, W Ndifon, NS Wingreen. How can vaccine designs against influenza and other viral diseases be made more effective? PLOS Pathogens, December 2010

Keyao Pan, Jinxue Long, Haoxin Sun, Gregory J. Tobin, Peter L. Nara, Michael W. Deem
Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein
J Mol Evol. 2011 January; 72(1): 90?103. Published online 2010 November 18.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033527/?tool=pmcentrez

Pan K, J Long, XZ Sun, GJ Tobin, PL Nara and MW Deem. Selective Pressure to Increase Charge in Immunodominant Epitopes of the H3 Hemagglutinin Influenza Protein., J Mol Evol. 2010 Nov 18

Wolfram JH, Nara PL. Exchange and sharing of new information, experiences, and approaches to controlling, reducing, and eventually eradicating different types of diseases. Conclusion. Vaccine. 2010 Oct 1;28 Suppl 5:F85-8. No abstract available.
http://www.ncbi.nlm.nih.gov/pubmed/20891047

Wolfram JH, Nara PL.
Brucellosis as a Transboudary Infection of Animals and Humans which Needs to be Managed by Cooperative Efforts of Different Countries. Introduction. Vaccine. 2010 Oct 1;28 Suppl 5:F1-2.
http://www.ncbi.nlm.nih.gov/pubmed/20850687

Bushnell RV , Tobin JK, Long J, Schultz-Cherry S, Chaudhuri AR, Nara PL, Tobin GJ.
Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein. Virol J. 2010 Aug 24;7:200.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939558/?tool=pmcentrez

Eguchi-Ogawa T, Wertz N, Sun XZ, Puimi F, Uenishi H, Wells K, Chardon P, Tobin GJ, Butler JE.
Antibody repertoire development in fetal and neonatal piglets. XI. The relationship of variable heavy chain gene usage and the genomic organization of the variable heavy chain locus.
J Immunol. 2010 Apr 1;184(7):3734-42. Epub 2010 Mar 5.
http://www.ncbi.nlm.nih.gov/pubmed/20207992

Sponseller BA, Strait E, Jergens A, Trujillo J, Harmon K, Koster L, Jenkins-Moore M, Killian M, Swenson S, Bender H, Waller K, Miles K, Pearce T, Yoon KJ, Nara P. Influenza A pandemic (H1N1) 2009 virus infection in domestic cat.
Emerg Infect Dis. 2010 Mar;16(3):534-7.
http://www.ncbi.nlm.nih.gov/pubmed/20202440

Arens M.Q., Buller R.S., Rankin A., Mason S., Whetsell1 A., Agapov E., Lee W.-M., and Storch G.A. 2010. Comparison of the Eragen Multi-Code® Respiratory Virus Panel with Conventional Viral Testing and Real-Time Multiplex PCR Assays for Respiratory Viruses.  J Clin Microbiol. 48:2387-95.

Bochkova, Y. A., Palmenberg A. C., Lee W.-M., Rathe J. A., Amineva S. P., Sun X., T. R., Pasicd N., Jarjour N., Liggett S. B., and Gern J. E.. 2010. Molecular modeling, organ culture and reverse genetics of the emerging pathogen human rhinovirus C. Nature Medicine 17:627-632.

Bushnell RV, Tobin JK, Long J, Schultz-Cherry S, Chaudhuri AR, Nara PL, Tobin GJ.  Serological characterization of guinea pigs infected with H3N2 human influenza or immunized with hemagglutinin protein. Virol J 7:200.  2010.

Eguchi-Ogawa T, Wertz N, Sun XZ, Puimi F, Uenishi H, Wells K, Chardon P, Tobin GJ, Butler JE. Antibody repertoire development in fetal and neonatal piglets. XI. The relationship of variable heavy chain gene usage and the genomic organization of the variable heavy chain locus. J Immunol.184:3734-42.2010

Jurgeit, A., S. Moese, P. Roulin, A. Dorsch, M. Lötzerich, W.-M. Lee, and U. F. Greber. 2010. An RNA replication-center assay for high content image-based quantifications of human rhinovirus and coxsackievirus infections. Virology Journal. 7:264 -277.

Linderholm A., Onitsuka J., Xu C., Chiu M., Lee W.-M., and Harper R. 2010 All-Trans Retinoic Acid Mediates Duox2 Expression and Function in Respiratory Tract Epithelium. Am J Physiol Lung Cell Mol Physiol. 299:L215-221.

Olenec J.P., Kim W.K., Lee W.-M., Vang F., Pappas T.E., Salazar L.E., Evans M.D., Bork J., Roberg K., Lemanske R.F. Jr, Gern J.E. 2010. Weekly Monitoring of Children with Asthma for Infections and Illness During Common Cold Seasons. J Allergy Clin Immunol. 125:1001-1006

Turner R.B, and Lee W.-M. 2009 Rhinovirus. In: Richman DD, Whitley RJ, Hayden FG, eds. Clinical virology. 3rd ed. Washington, D.C.: ASM Press. 1063-1082.

Tobin GJ, Trujillo JD, Bushnell RV, Lin G, Chaudhuri AR,Long J, Barrera J, Pena L, Grubman, MJ and Nara PL.
Deceptive imprinting and immune refocusing in vaccine design. Vaccine 26:6189-6199, 2008.
http://www.ncbi.nlm.nih.gov/pubmed/18852005

Nara PL, Nara D, Chaudhuri AR, Lin G, and Tobin GJ
Perspectives on advancing preventative medicine through vaccinology at the comparative veterinary, human and conservation medicine interface: Not missing the opportunities. Vaccine 26:6200-6211, 2008.
http://www.ncbi.nlm.nih.gov/pubmed/18708109

Lin G, Nara PL.
Designing immunogens to elicit broadly neutralizing antibodies to the HIV-1 envelope glycoprotein. Curr HIV Res. 5:514-41, 2007 Review.
http://www.ncbi.nlm.nih.gov/pubmed/18045109

Gay CG, Richie TL, Pastoret PP, Minguez-Tudela I, de Baetselier P, Göbel T, Goddeeris B, Kaiser P, Morrison I, Sánchez-Vizcaíno JM, Anderson K, Baillie LW, Brown WC, Estes DM, Herrera E, Nara PL, Ockenhouse CF, Roth JA, Sztein MB.    Advances in immunology and vaccine discovery report of the United States-European Commission workshop.
Vaccine. 2007 Oct 10;25(41):7007-11. Epub 2007 Aug 6.
http://www.ncbi.nlm.nih.gov/pubmed/17728022

Nara PL, Lin G. HIV-1: the confounding variables of virus neutralization.
Curr Drug Targets Infect Disord. 2005 Jun;5(2):157-70. Review.
http://www.ncbi.nlm.nih.gov/pubmed/15975021

Nara PL. The status and role of vaccines in the U.S. food animal industry. Implications for biological terrorism.
Ann N Y Acad Sci. 1999;894:206-17. Review.
http://www.ncbi.nlm.nih.gov/pubmed/10681992

Kohler H, Muller S, Schiffer M, Nara PL. Few clues for AIDS vaccines from structural data on gp120 and its receptors and antibodies
J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):315-6.
http://www.ncbi.nlm.nih.gov/pubmed/10077183

Garrity RR, Rimmelzwaan G, Minassian A, Tsai WP, Lin G, de Jong JJ, Goudsmit J, Nara PL. Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope.
J Immunol. 1997 Jul 1;159(1):279-89.
http://www.ncbi.nlm.nih.gov/pubmed/9200464

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